Translational research: MICROBIOME MODULATION
This WP will use the data from existing and ongoing interventional studies
performed at the UvA, aiming at modulation of the oral and/or gut microbiome and performed at UvA. This includes, but is not limited to, ongoing intervention studies on role of (a protein- rich) diet in both elderly (EU PROMISS) and in type 2 diabetes (JPI Microdiet), as well as the effect of donor fecal transplantation on the oral and fecal microbiota composition (FATMED study), effects of pre- (PROM) and probiotics (PROH-ACT) on the resilience of the oral ecosystem towards gingival inflammation.
Discovery of preventive approaches for microbiome health
The output of these studies will be used for in-silico modelling of microbiome resilience towards dysbiosis as well as reciprocal interactions between oral and fecal microbiota. This hopefully can lead to discovery of preventive approaches for microbiome health. To validate the in-silico modeling, classical microbial cultures will be initiated using consortia of the identified microorganisms to study their network intervention. After the pilot phase of experiments, interaction with (commercial) parties in the Amsterdam region will be sought with help of IXA to further valorize this knowledge.
Optimization of the data collection and data handling INFRASTRUCTURE for microbiomics
Observational research: MICROBIOME-HOST PHENOTYPE ASSOCIATIONS